Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics
Author:
Funder
Leverhulme Trust
Publisher
Springer Science and Business Media LLC
Subject
Physical and Theoretical Chemistry,Computer Science Applications,Drug Discovery
Link
https://link.springer.com/content/pdf/10.1007/s10822-020-00338-6.pdf
Reference48 articles.
1. Kotarsky K, Nilsson NE, Flodgren E et al (2003) A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem Biophys Res Commun 301:406–410
2. Itoh Y, Kawamata Y, Harada M et al (2003) Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422:173–176
3. Edfalk S, Steneberg P, Edlund H (2008) Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes 57:2280–2287
4. World Health Organization (2016) Diabetes mellitus fact sheet. https://www.who.int/news-room/fact-sheets/detail/diabetes
5. Watterson KR, Hudson BD, Ulven T, Milligan G (2014) Treatment of type 2 diabetes by free fatty acid receptor agonists. Front Endocrinol (Lausanne) 5:137
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