Affiliation:
1. Departamento de Bioquímica, Facultad de Medicina, Alcalá de Henares-Madrid, Spain
Abstract
Vasoactive intestinal peptide (VIP) and the β-adrenergic agonist isoproterenol stimulated cyclic AMP formation through independent receptors in isolated epithelial ceils of rat ventral prostate. The specific β-adrenergic antagonist propranolol inhibited the stimulatory effect of isoproterenol but not that of VIP. Besides small differences in the efficiency of both agents, results indicated that isoproterenol was 500 times less potent than VIP. Acetylcholine did not modify the basal cyclic AMP levels but inhibited the accumulation of the cyclic nucleotide in the presence of either VIP or isoproterenol. The inhibitory action of muscarinic receptors was calcium-dependent. The coexistence of receptors for cholinergic, adrenergic and peptidergic agents which can regulate cyclic AMP suggests that the functions of prostatic epithelium may be interdependently controlled by multiple neural effectors.
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference21 articles.
1. Farnsworth WE (1980) in:Male Accessory Sex Glands (Spring-Mills E & Hafez ESE, (eds), pp 155?182, Elsevier/North Holland, Amsterdam.
2. Webber MM (1981) in:The Prostatic Cell: Structure and Function, Part B (Murphy GP, Sandberg AA & Karr JP, eds), pp. 63?68, A. R. Liss, New York.
3. Keenan EJ, Kemp ED, Ramsey EE, Garrison LB, Pearse HD & Hodges CV (1979) J. Urol.122, 43?45.
4. Dave JR & Witorsch RJ (1982) Endocrinology111, 2144?2146.
5. Shima S, Kawashima Y, Hirai M & Kouyama H (1980) Biochim. Biophys. Acta628, 255?262.
Cited by
15 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献