Alpha1-antitrypsin: Structure, function and molecular biology of the gene-Reference-Cited by-同舟云学术

Alpha1-antitrypsin: Structure, function and molecular biology of the gene

Published:1989-04-01 Issue:2 Volume:9 Page:129-138
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Kalsheker N.¹

Affiliation:

1. Department of Medical Biochemistry, University of Wales College of Medicine, Royal Infirmary, Newport Road, Cardiff CF2 1SZ

Abstract

Alpha1-antitrypsin (AAT) deficiency is one of the commonest inherited disorders in white Caucasians. This association has provided major insights into the pathogenesis of chronic lung disease. The three dimensional structure of the protein and the structure of the gene have been determined. Some of the signals required for regulation of expression and tissue-specificity have been defined. Genetic manipulation of active site residues may provide a new generation of biological compounds with potential therapeutic applications.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/9/2/129/472323/bsr0090129.pdf

Reference59 articles.

1. Carrell, R. W., Jeppsson, J.-O., Laurell, C.-B., Brennan, S. O., Owen, M. C., Vaughan, L. and Boswell, D. R. (1983)Nature (Lond.)298:329.

2. Laurell, C.-B. and Eriksson, S. (1963)Scand. J. Lab. Invest. 15:132.

3. Kilburn, K. H. and McKenzie, W. (1975)Science 189:634.

4. Carp, H., Miller, F. and Hoidal, J. R. (1982)Proc. Natl. Acad. Sci. USA 79:2041.

5. Carrell, R. W., Jeppsson, J.-O., Vaughan, L., Brennan, S., Owen, M. and Boswell, D. R. (1981)FEBS Lett. 135:301.

Cited by 42 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Computational Tools to Assist in Analyzing Effects of the SERPINA1 Gene Variation on Alpha-1 Antitrypsin (AAT);Genes;2024-03-06

2. Genetic characterization of potential venom resistance proteins in California ground squirrels ( Otospermophilus beecheyi ) using transcriptome analyses;Journal of Experimental Zoology Part B: Molecular and Developmental Evolution;2022-05-24

3. Development of anti-inflammatory peptidomimetics based on the structure of human alpha1-antitrypsin;European Journal of Medicinal Chemistry;2022-01

4. Protease-Specific Biomarkers to Analyse Protease Inhibitors for Emphysema Associated with Alpha 1-Antitrypsin Deficiency. An Overview of Current Approaches;International Journal of Molecular Sciences;2021-01-21

5. The Enzymology of Human Milk;Agents of Change;2021