Trospium chloride: A quaternary amine with unique pharmacologic properties

Author:

Pak Raymond W.,Petrou Steven P.,Staskin David R.

Publisher

Springer Science and Business Media LLC

Subject

Urology,General Medicine

Reference39 articles.

1. Friebe TP, Mutschler E, Lambrecht G: Muskarinrezeptor-subtypen: pharmakologische charakterisierung, molekulare struktur lokglisation, function und receptor-effector-kopplung. Pharm Z Wiss 1993, 1:3–11.

2. Igawa Y: Discussion: functional role of M1, M2, and M3 muscarinic receptors in overactive bladder. Urology 2000, 55(suppl 5A):47–49. Provides data on muscarinic receptor research and discusses the significance of receptor subtypes and effects on OAB pharmacotherapy.

3. Ikeda K, Kobayashi S, Suzuki M, et al.: M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch Pharmacol 2002, 366:97–103.

4. Schwantes U, Topfmeier P: Importance of pharmacological and physiochemical properties for tolerance of antimuscarinic drugs in the treatment of detrusor instability and detrusor hyperreflexia: chances for improvement of therapy. Int J Clin Pharmacol Ther 1999, 37:209–218. Reviews and highlights the importance of chemical structure in kinetic and dynamic properties.

5. Yoshimura N, Chancellor MB: Current and future pharmacological treatment for overactive bladder. J Urol 2002, 168:1897–1913. Comprehensive review of current research in OAB etiology and treatment. Projections of future avenues of therapy.

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