Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function-Reference-Cited by-同舟云学术

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function

Published:2018-07-10 Issue:5 Volume:113 Page:
ISSN:0300-8428
Container-title:Basic Research in Cardiology
language:en
Short-container-title:Basic Res Cardiol

Author:

Audia Jonathon P.,Yang Xi-Ming,Crockett Edward S.,Housley Nicole,Haq Ehtesham Ul,O’Donnell Kristen,Cohen Michael V.,Downey James M.,Alvarez Diego F.

Funder

Foundation for the National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

http://link.springer.com/article/10.1007/s00395-018-0692-z/fulltext.html

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2. Alvarez DF, Housley N, Koloteva A, Zhou C, O’Donnell K, Audia JP (2016) Caspase-1 activation protects lung endothelial barrier function during infection-induced stress. Am J Respir Cell Mol Biol 55:500–510. https://doi.org/10.1165/rcmb.2015-0386OC

3. Audia JP, Lindsey AS, Housley NA, Ochoa CR, Zhou C, Toba M, Oka M, Annamdevula NS, Fitzgerald MS, Frank DW, Alvarez DF (2013) In the absence of effector proteins, the Pseudomonas aeruginosa type three secretion system needle tip complex contributes to lung injury and systemic inflammatory responses. PLoS One 8:e81792. https://doi.org/10.1371/journal.pone.0081792

4. Barrabes JA, Inserte J, Mirabet M, Quiroga A, Hernando V, Figueras J, Garcia-Dorado D (2010) Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts. Thromb Haemost 104:128–135. https://doi.org/10.1160/TH09-07-0440

5. Bell RM, Sivaraman V, Kunuthur SP, Cohen MV, Downey JM, Yellon DM (2015) Cardioprotective properties of the platelet P2Y12 receptor inhibitor, cangrelor: protective in diabetics and reliant upon the presence of blood. Cardiovasc Drugs Ther 29:415–418. https://doi.org/10.1007/s10557-015-6609-2

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