Natural History of Eosinophilic Oesophagitis in Childhood
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s40124-016-0102-7.pdf
Reference36 articles.
1. • Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011;128:3–20. These expert committee guidelines represent an update of those published in 2007 and provide a reference document which revises and discusses available information up to publication in 2011. Recommendations for further research are also put forward.
2. • Dellon ES, Gonsalves N, Hirano I, et al. ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE) Am J Gastroenterol 2013;108:679–92. This clinical guideline adopts an evidence-based approach to the diagnosis and management of EoE and uses the GRADE system to assess the strength of the recommendations. Natural history is listed under outcomes and recommendation 19 states that “while knowledge of the natural history of EoE is limited, patients should be counselled about the high likelihood of symptom recurrence after discontinuing treatment due to the chronic nature of this disease” (Recommendation strong, moderate evidence).
3. •• Papadopoulou A, Koletzko S, Heuschkel R, et al. Management Guidelines of Eosinophilic Esophagitis in Childhood. JPGN 2014;58:107–118. This position paper of the Eosinophilic Esophagitis Working Group and the Gastroenterology Committee of ESPGHAN provides practice guidelines for the management of children and adolescents with EoE based on available evidence. With regard to the natural history of EoE in childhood, the authors point out that “there are no follow-up studies assessing the long-term consequences of persisting esophageal eosinophilia in asymptomatic patients” but that “the possibility of esophageal fibrosis and narrowing cannot be excluded”. Another interesting observation was that swallowed topical corticosteroids may not be as effective when there is ongoing exposure to relevant food allergens ie “allergy” may override the response to topical corticosteroids if used without an appropriate elimination diet.
4. Attwood SE, Smyrk TC, Demeester TR, Jones JB. Esophageal eosinophilia with dysphagia, a distinct clinicopathological syndrome. Dig Dis Sci. 1993;38:109–16.
5. • Kelly KJ, Lazenby AJ, Rowe PC, et al. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109(5):1503–12. This landmark study was the first to demonstrate the role of food allergy in EoE by successfully treating both the oesophageal inflammation and the symptoms with an elemental diet.
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