Synthesis and pharmacological properties of polysubstituted 2-amino-4H-pyran-3-carbonitrile derivatives

Author:

Tashrifi Zahra,Mohammadi-Khanaposhtani Mohammad,Hamedifar Haleh,Larijani Bagher,Ansari Samira,Mahdavi Mohammad

Publisher

Springer Science and Business Media LLC

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis

Reference127 articles.

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2. Kalaria PN, Satasia SP, Raval DK (2014) Synthesis, characterization and biological screening of novel 5-imidazopyrazole incorporated fused pyran motifs under microwave irradiation. New J Chem 38:1512–1521. https://doi.org/10.1039/C3NJ01327H

3. Kemnitzer W, Drewe J, Jiang S, Zhang H, Zhao J, Crogan-Grundy C, Xu L, Lamothe S, Gourdeau H, Denis R, Tseng B (2007) Discovery of 4-aryl-4 H-chromenes as a new series of apoptosis inducers using a cell-and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7, 8-positions. J Med Chem 50:2858–2864. https://doi.org/10.1021/jm070216c

4. Zhang G, Zhang Y, Yan J, Chen R, Wang S, Ma Y, Wang R (2012) One-pot enantioselective synthesis of functionalized pyranocoumarins and 2-amino-4 H-chromenes: discovery of a type of potent antibacterial agent. J Org Chem 77:878–888. https://doi.org/10.1021/jo202020m

5. Erichsen MN, Huynh TH, Abrahamsen B, Bastlund JF, Bundgaard C, Monrad O, Bekker-Jensen A, Nielsen CW, Frydenvang K, Jensen AA, Bunch L (2010) Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5, 6, 7, 8-tetrahydro-4 H-chromene-3-carbonitrile (UCPH-101). J Med Chem 53:7180–7191. https://doi.org/10.1021/jm1009154

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