Abstract
AbstractDisclosure of new molecular probes as chromogenic and fluorogenic cation sensors is scientifically exigent work. Recently chalcone derivatives gained more attention because of their structural variability. A suitable donor and acceptor groups separated by delocalized π-orbitals display excellent chromogenic and fluorogenic properties because of intramolecular charge transfer (ICT). These designed molecular frameworks provide the coordination sites to the incoming metal ions results in small changes in the optical properties. In a typical sensing behavior, coordination leads to a large conjugation plane with the probe resulted in hypo/hyperchromic shifts or red/blue shifts. In this review, we tried to converge the reported chalcone-derived sensors and explored the design, synthesis, metal ion sensing mechanism, and practical application of the probes. We expect that this review gives a basic outline for researchers to explore the field of chalcone-based sensors further.
Funder
Manipal Academy of Higher Education, Manipal
Publisher
Springer Science and Business Media LLC
Subject
Law,Clinical Biochemistry,Spectroscopy,Sociology and Political Science,Social Sciences (miscellaneous),Clinical Psychology,Biochemistry
Reference138 articles.
1. Shibata S (1994) Anti-tumorigenic chalcones. Stem Cells 12:44–52
2. Lipinski CF, Oliveira AA, Honorio KM et al (2018) A molecular modeling study of combretastatin-like chalcones as anticancer agents using PLS, ANN and consensus models. Struct Chem 29:957–965
3. Wang L, Yang X, Zhang Y et al (2019) Anti-inflammatory Chalcone-Isoflavone Dimers and Chalcone Dimers from Caragana jubata. J Nat Prod 82:2761–2767. https://doi.org/10.1021/acs.jnatprod.9b00365
4. Chen Y-F, Wu S-N, Gao J-M et al (2020) The antioxidant, anti-inflammatory, and neuroprotective properties of the synthetic chalcone derivative AN07. Molecules 2:1–20
5. Cheng P, Yang L, Huang X et al (2020) Chalcone hybrids and their antimalarial activity. Arch Pharm (Weinheim) 353:1–10. https://doi.org/10.1002/ardp.201900350
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献