Influencing Factors and New Reference Intervals of Adult Thyroid Volume in Iodine-Sufficient Areas of China

Author:

Lin Zheyu,Lu Cihang,Teng Di,Sun Ying,Liu Tingting,Li Yongze,Shan Zhongyan,Teng Weiping, ,

Abstract

AbstractThe diagnosis of goiter is based on the thyroid volume measured by ultrasound in which iodine plays an important role. The purpose of this study was to evaluate the factors that affect thyroid volume and update the reference range of thyroid volume to provide a new basis for the diagnosis and treatment of goiter. A study population from mainland China was evaluated in the Thyroid disorders, Iodine status and Diabetes Epidemiological (TIDE) study. Thyroid size was measured by ultrasound, and thyroid volume was calculated. A quantile regression model was used to analyze the influence of related factors on the thyroid volume at each percentile. The median urinary iodine concentration (UIC) was 185.54 μg/l. The quantile regression model suggested that body surface area (BSA) and thyroid-stimulating hormone (TSH) were positive and negative factors for thyroid volume, respectively (p < 0.01). Excess iodine reduces the median and lower limits of thyroid volume. In iodine-sufficient areas, smoking is no longer a risk factor. The reference value range of thyroid volume stratified by sex was 3.92–19.06 ml for males and 3.1–16.17 ml for females. The maximum reference ranges for stratification by sex and BSA were 4.25–20.98 ml for men and 3.44–18.31 ml for women. The iodine nutrition level of the population in mainland China is sufficient. Iodine has the potential to alter the effect of certain factors on thyroid volume and effect is not regional. The new reference interval of adult thyroid volume based on sex and BSA has been updated, which can be used as a reliable reference for updating the diagnostic criteria of endemic goiter.

Funder

the Research Fund for Public Welfare, National Health and Family Planning Commission of China

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry (medical),Inorganic Chemistry,Clinical Biochemistry,General Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

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