Abstract
AbstractHuman orf disease (called ecthyma contagiosum or contagious/infectious pustular dermatitis in animals) was confirmed on the fingers of both hands of a 24-year-old female, after feeding diseased lambs with a nursing bottle in April 2023. In addition to skin symptoms, she had low-grade fever (37.6°C) and swollen lymph nodes in both axilla. The presence of orf virus (genus Parapoxvirus, family Poxviridae) was confirmed, and this strain, Baja/2023/HUN (OR372161-OR372163), was found to have > 98% nucleotide sequence identity to sheep-origin orf viruses in four tested genome regions (ORF011/B2L, ORF019, ORF020/VIR, and ORF056). This is the first report of a human case of infection with the neglected zoonotic orf virus in Hungary.
Publisher
Springer Science and Business Media LLC
Reference18 articles.
1. McInnes CJ, Damon IK, Smith GL, McFadden G, Isaacs SN, Roper RL, Evans DH, Damaso CR, Carulei O, Wise LM, Lefkowitz EJ (2023) ICTV virus taxonomy profile: Poxviridae 2023. J Gen Virol 104:001849
2. Veraldi S, Esposito L, Pontini P, Vaira F, Nazzaro G (2019) Feast of sacrifice and orf, Milan, Italy, 2015–2018. Emerg Infect Dis 25(8):1586–1586
3. Bergqvist C, Kurban M, Abbas O (2017) Orf virus infection. Rev Med Virol 27(4):e1932
4. Coradduzza E, Sanna D, Rocchigiani AM, Pintus D, Scarpa F, Scivoli R, Bechere R, Dettori MA, Montesu MA, Marras V, Lobrano R, Ligios C, Puggioni G (2021) Molecular insights into the genetic variability of ORF virus in a Mediterranean region (Sardinia, Italy). Life (Basel) 11(5):416
5. Kitchen M, Müller H, Zobl A, Windisch A, Romani N, Huemer H (2014) Orf virus infection in a hunter in Western Austria, presumably transmitted by game. Acta Derm Venereol 94:212–214