Abstract
AbstractProtein self-association is a widespread phenomenon that results in the formation of multimeric protein structures with critical roles in cellular processes. Protein self-association can lead to finite protein complexes or open-ended, and potentially, infinite structures. This review explores the concept of protein agglomeration, a process that results from the infinite self-assembly of folded proteins. We highlight its differences from other better-described processes with similar macroscopic features, such as aggregation and liquid-liquid phase separation. We review the sequence, structural, and biophysical factors influencing protein agglomeration. Lastly, we briefly discuss the implications of agglomeration in evolution, disease, and aging. Overall, this review highlights the need to study protein agglomeration for a better understanding of cellular processes.
Funder
Instituto de Biología Molecular de Barcelona
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Structural Biology,Biophysics
Reference178 articles.
1. Ahnert SE, Marsh JA, Hernández H, Robinson CV, Teichmann SA (2015) Principles of assembly reveal a periodic table of protein complexes. Science 350(6266):aaa2245. https://doi.org/10.1126/science.aaa2245
2. Alberti S, Halfmann R, King O, Kapila A, Lindquist S (2009) A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell 137(1):146–158. https://doi.org/10.1016/j.cell.2009.02.044
3. Alberti S, Hyman AA (2021) Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing. Nat Rev Mol Cell Biol 22(3):196–213. https://doi.org/10.1038/s41580-020-00326-6
4. Alberts B, Johnson A, Lewis J, Walter P, Raff M, Roberts K (2002) Molecular Biology of the Cell 4th Edition: International Student Edition. Routledge https://play.google.com/store/books/details?id=ozigkQEACAAJ
5. Alex JM, Rennie ML, Engilberge S, Lehoczki G, Dorottya H, Fizil Á, Batta G, Crowley PB (2019) Calixarene-mediated assembly of a small antifungal protein. IUCrJ 6(Pt 2):238–247. https://doi.org/10.1107/S2052252519000411
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