Multi-enzyme cascade for sustainable synthesis of l-threo-phenylserine by modulating aldehydes inhibition and kinetic/thermodynamic controls
Author:
Funder
National Basic Research Program of China
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s43393-022-00102-x.pdf
Reference31 articles.
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3. Zhao W, Yang B, Zha R, Zhang Z, Tang S, Pan Y, Qi N, Zhu L, Wang B. A recombinant L-threonine aldolase with high diastereoselectivity in the synthesis of L-threo-dihydroxyphenylserine. Biochem Eng J. 2020. https://doi.org/10.1016/j.bej.2020.107852.
4. Lamotte G, Holmes C, Sullivan P, Goldstein DS. Substantial renal conversion of L-threo-3,4-dihydroxyphenylserine (droxidopa) to norepinephrine in patients with neurogenic orthostatic hypotension. Clin Auton Res. 2019;29(1):113–7. https://doi.org/10.1007/s10286-018-0564-5.
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