Inhibitors of ribonucleotide reductase alter DNA repair in human fibroblasts through specific depletion of purine deoxynucleotide triphosphates

Author:

Snyder Ronald D.

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Cell Biology,Toxicology

Reference38 articles.

1. AYUSAWA, D., IWATA, K., AND SENO, T. (1983). Unusual sensitivity to bleomycin and joint resistance to 9-B-D arabinofuranosyl adenine and 1-B-D-arabinofuranosyl cytosine of mouse FM3A cell mutants with altered ribonucleotide reductase and thymidylate synthetase, Cancer Res. 43:814?818.

2. BEN-HUR, E., AND BEN-ISHAI, R. (1971). DNA repair in ultraviolet light irradiated HeLa cells and its reversible inhibition by hydroxyurea. Photochem. Phtobiol. 13:337?345.

3. BROCKMAN, R.W., SHADDIX, W. LASTER, JR., W.R. AND SHABEL, JR., F.M. (1970). Inhibition of ribonucleotide reductase, DNA synthesis and L1210 leukemia by guanazole. Cancer Res. 30:2358?2368.

4. CLARKSON, J. (1978). Enhancement of repair replication in mammalian cells by hydroxyurea. Mutat. Res. 52:273?284.

5. CLEAVER, J.E. (1969). Repair replication of mammalian cell DNA: Effects of compounds that inhibit DNA synthesis on dark repair. Radiat. Res. 37:334?348.

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