Abstract
AbstractIn this work, new chitosan-based Schiff bases were synthesized by the reaction of chitosan with quinolinone and pyranoquinolinone giving CSQ, and CSP, respectively. The novel Chitosan Schiff bases were grafted on silver nanoparticles providing CSQ/Ag, CSP/Ag structures. Characterization of isolated compounds was carried out by FT-IR, TGA, XRD, SEM, and TEM. The target compounds CSQ, CSP, CSQ/Ag, and CSP/Ag were evaluated as antitumor agents against three cancer cell lines, liver (HepG-2), colon (HCT-116), and breast (MCF-7). Compound CSQ/Ag disclosed potent cytotoxic effect with IC50 values in the range of 41.9–55.1 μg/ml in comparison with 5-fluorouracil against different cancer cell lines. Besides, the antioxidant activity of chitosan and its quinolinone and pyranoquinolinone analogues was assessed as radical scavengers versus 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH%). The compound CSQ/Ag emerged as the most active member in scavenging the DPPH radicals. The obtained findings proved that the new Schiff bases/silver nanoparticles of chitosan showed higher antiproliferative and antioxidant activities than the blank CS and would be highly applicable in biomedical fields.
Graphical abstract
Publisher
Springer Science and Business Media LLC
Subject
Materials Chemistry,Polymers and Plastics,Condensed Matter Physics,General Chemistry
Cited by
16 articles.
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