Modulation of Brain Injury as a Target of Adjunctive Therapy in Bacterial Meningitis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases
Link
http://link.springer.com/content/pdf/10.1007/s11908-010-0116-1.pdf
Reference48 articles.
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2. • Ramakrishnan M, Ulland AJ, Steinhardt LC, et al.: Sequelae due to bacterial meningitis among African children: a systematic literature review. BMC Med 2009, 7:47. This article gives a comprehensive review of data on sequelae of bacterial meningitis in children from the African continent. The highest in-hospital case fatality ratios observed were for pneumococcal meningitis (median = 35%) and Haemophilus influenzae type B (Hib) meningitis (median = 25%). Moreover, pneumococcal and HiB meningitis cause clinically evident sequelae in a quarter of survivors prior to hospital discharge.
3. Nau R, Soto A, Bruck W: Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J Neuropathol Exp Neurol 1999, 58:265–274.
4. Koedel U, Klein M, Pfister HW: New understandings on the pathophysiology of bacterial meningitis. Curr Opin Infect Dis 2010, 23:217–223.
5. • Assiri AM, Alasmari FA, Zimmerman VA, et al.: Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: a meta-analysis. Mayo Clin Proc 2009, 84:403–409. A systematic review and meta-analysis that was performed by searching several databases for reports (published from January 1966 through February 2008) of placebo-controlled randomized trials of corticosteroid use in the treatment of adolescents and adults with acute bacterial meningitis. The meta-analysis suggests that adjunctive corticosteroids are beneficial in the treatment of adolescents and adults with bacterial meningitis in patient populations similar to those seen in high-income countries and in areas with a low prevalence of HIV infection.
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