Effects of membrane lipid and fluidity modifications on HIV-1 infectibility of primate lymphocytes in vitro-Reference-Cited by-同舟云学术

Effects of membrane lipid and fluidity modifications on HIV-1 infectibility of primate lymphocytes in vitro

Published:1990-06-01 Issue:3 Volume:10 Page:263-270
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Zimmer J. Pascal¹,Lehr Hans A.,Hübner Christoph²,Lindner Stephan G.²,Ramsperger Ralf,Claussen Matthias²,Kohlschütter Alfried²,Schmitz Herbert

Affiliation:

1. Department of Virology, Bernhard Nocht Institute for Nautical and Tropical Diseases, Bernhard-Nocht-Str. 74, D-2000 Hamburg 4, West Germany

2. Department of Pediatrics, University of Hamburg, Martinistr. 52, D-2000 Hamburg 20, West Germany

Abstract

Although most non-human primates, except the chimpanzee and the gibbon in vivo are not infectible by HIV-1, lymphocytes of several of these species can be infected by HIV-1 in vitro. In order to investigate whether the in vitro infectibility of primate lymphocytes might be attributed to plasma membrane adaptation processes or to serum factors, we compared HIV-1 infectibility of cultivated peripheral blood lymphocytes of macaques and of baboons on day one and on day ten of cultivation. These data were correlated to plasma membrane lipid composition and membrane fluidity. We found a correlation between increased HIV-1 in vitro infectibility and changes in plasma membrane lipid composition resulting in decreased membrane fluidity of cultured primate lymphocytes.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/10/3/263/468139/bsr0100263.pdf

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