Detection of nimesulide metabolites in rat plasma and hepatic subcellular fractions by HPLC-UV/DAD and LC-MS/MS studies-Reference-Cited by-同舟云学术

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Detection of nimesulide metabolites in rat plasma and hepatic subcellular fractions by HPLC-UV/DAD and LC-MS/MS studies

Published:2005-03 Issue:1-2 Volume:30 Page:127-134
ISSN:0378-7966
Container-title:European Journal of Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Eur. J. Drug Metab. Pharmacokinet.

Author:

Küçükgüzel Ş. Güniz,Küçükgüzel İlkay,Oral Başak,Sezen Sena,Rollas Sevİm

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Link

http://link.springer.com/content/pdf/10.1007/BF03226418.pdf

Reference22 articles.

1. Boelsterli UA (2002): Mechanisms of NSAID-Induced Hepatotoxicity. Drug Safety, 25, 633–648.

2. Ferrario P, Bianchi M (2003): Simultaneous determination of nimesulide and hydroxynimesulide in rat plasma, cerebrospinal fluid and brain by liquid chromatography using solid-phase extraction. J. Chromatogr. B. 785, 227–236.

3. Bevilacqua M, Vago T, Baldi G, Renesto E, Dallegri F, Norbiato G (1994): Nimesulide decreases superoxide production by inhibiting phosphodiesterase type IV. Eur.J.Pharmacol., 268, 415–423.

4. Cignarella G, Vianella P, Berti F, Rossani G (1996): Synthesis and pharmacological evaluation of derivatives structurally related to nimesulide. EurJ. Med. Chem. 31, 359–364.

5. Capsoni F, Venegoni E, Minonzio F, Ongari, AM, Maresca V, Zanussi C (1987): Inhibition of neutrophil oxidative metabolism by nimesulide. Agents Actions 21, 121–129.

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