Komagataella pastoris KM71H Mitigates Depressive-Like Phenotype, Preserving Intestinal Barrier Integrity and Modulating the Gut Microbiota in Mice

Author:

Birmann Paloma T.,Casaril Angela M.,Pesarico Ana Paula,Rodrigues Rafael R.,Conceição Fabricio R.,Sousa Fernanda Severo Sabedra,Collares Tiago,Seixas Fabiana K.,Savegnago LucielliORCID

Funder

CAPES

CNPq

FAPERGRS

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Reference79 articles.

1. Birmann PT, Casaril AM, Pesarico AP, Caballero PS, Smaniotto TA, Rodrigues RR, Moreira AN, Conceicao FR, Sousa FSS, Collares T, Seixas FK, Franca RT, Corcini CD, Savegnago L (2021) Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: a proposal for a new probiotic with antidepressant-like effect. Pharmacol Res 105740. https://doi.org/10.1016/j.phrs.2021.105740

2. Franca RC, Conceicao FR, Mendonca M, Haubert L, Sabadin G, de Oliveira PD, Amaral MG, Silva WP, Moreira AN (2015) Pichia pastoris X-33 has probiotic properties with remarkable antibacterial activity against Salmonella Typhimurium. Appl Microbiol Biotechnol 99(19):7953–7961. https://doi.org/10.1007/s00253-015-6696-9

3. de Los G, Santos D, de Los G, Santos JR, Gil-Turnes C, Gaboardi G, Fernandes Silva L, Franca R, Gevehr Fernandes C, Rochedo Conceicao F (2018) Probiotic effect of Pichia pastoris X-33 produced in parboiled rice effluent and YPD medium on broiler chickens. PLoS One 13(2):e0192904. https://doi.org/10.1371/journal.pone.0192904

4. Evrensel A, Tarhan KN (2021) Emerging role of Gut-microbiota-brain axis in depression and therapeutic implication. Prog Neuro-Psychopharmacol Biol Psychiatry 106:110138. https://doi.org/10.1016/j.pnpbp.2020.110138

5. Madison A, Kiecolt-Glaser JK (2019) Stress, depression, diet, and the gut microbiota: human-bacteria interactions at the core of psychoneuroimmunology and nutrition. Curr Opin Behav Sci 28:105–110. https://doi.org/10.1016/j.cobeha.2019.01.011

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