Lost in elimination: mechanisms of axonal loss

Abstract

Abstract Axonal loss is an important process both dur­ing development and diseases of the ner­vous system. While the molecular mecha­nisms that mediate axonal loss are largely elusive, modern imaging technology affords an increasingly clear view of the cellular processes that allow nerve cells to shed individiual axon branches or even dismantle entire parts of their axonal projections. The present review discusses the characteristics of post-traumatic Wallerian degeneration, the process of axonal loss currently best understood. Subsequently, the properties of a number of recently discovered axonal loss phenome­na are described. These phenomena explain some of the axonal loss that occurs locally after axon transection, during neuro-inflammatory insults, and as part of normal neurode­velopment.