Off-target effects of base editors: what we know and how we can reduce it
Author:
Funder
ministry of science and higher education of the russian federation.
Publisher
Springer Science and Business Media LLC
Subject
Genetics,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00294-021-01211-1.pdf
Reference61 articles.
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2. Chu VT, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, Kuhn R (2015) Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotech 33:543–548
3. Doman JL, Raguram A, Newby GA, Liu DR (2020) Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors. Nat Biotechnol 38:620–628
4. Eid A, Alshareef S, Mahfouz MM (2018) CRISPR base editors: genome editing without double-stranded breaks. Biochem J 475(11):1955–1964. https://doi.org/10.1042/BCJ20170793
5. Epinat JC, Arnould S, Chames P et al (2003) A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells. Nucleic Acids Res 31(11):2952–2962. https://doi.org/10.1093/nar/gkg375
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