Author:
Peter Martin F.,Kalienkova Valeria,Paulino Cristina
Abstract
AbstractThe sperm-specific Na+/H+ exchanger SLC9C1 stands out by its unique tripartite domain composition. It is the first known secondary-active transporter which is directly activated by membrane voltage via a voltage-sensing domain (VSD). Our cryo-EM structures of sea urchin SLC9C1 reveal the domain arrangement and new structural coupling elements, allowing us to propose a mechanism for a voltage-activated alternative access mechanism.
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Biotechnology