Mechanismen der Cristae-Biogenese in Humanparasiten

Abstract

AbstractMitochondrial energy conversion depends on an intricately folded membrane structure, generated by oligomerisation of ATP synthase dimers. However, morphology of cristae membranes varies greatly between different organisms. Recent studies have revealed the unique ATP synthase assemblies of the causative agents of toxoplasmosis and sleeping sickness, giving insight into the role of parasite-specific sub-units in complex assembly, mitochondrial function and parasite fitness.