Veränderte T-Zell-Reaktion gegen Hefepilze bei chronischer Darmentzündung

Abstract

AbstractInappropriate CD4+ T cell responses against species of the intestinal microbiome have been suggested to contribute to the chronic inflammation of Crohn’s disease (CD). However, the microbial species that drive such inappropriate CD4+ T cell responses and the pathogenic T cell functions in CD remain largely unknown. Our work provides evidence that aberrant cytotoxic Th 1 cells directed against both commensal and food-derived yeasts may contribute to the inflammatory immune response in patients with CD.