Probing the Relationship Between Detected Ion Intensity, Laser Fluence, and Beam Profile in Thin Film and Tissue in MALDI MSI
Author:
Affiliation:
1. National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory (NPL), TW11 0LW, Teddington, UK
2. School of Pharmacy, University of Nottingham, NG7 2RD, Nottingham, UK
Funder
Technology Strategy Board
Publisher
American Chemical Society (ACS)
Subject
Spectroscopy,Structural Biology
Link
http://link.springer.com/content/pdf/10.1007/s13361-016-1414-0.pdf
Reference28 articles.
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3. Dreisewerd, K., Schurenberg, M., Karas, M., Hillenkamp, F.: Influence of the laser intensity and spot size on the desorption of molecules and ions in matrix-assisted laser-desorption ionization with a uniform beam profile. Int. J. Mass Spectrom 141, 127–148 (1995)
4. Dreisewerd, K.: The desorption process in MALDI. Chem. Rev. 103, 395–425 (2003)
5. Knochenmuss, R., Zhigilei, L.V.: Molecular dynamics simulations of MALDI: laser fluence and pulse width dependence of plume characteristics and consequences for matrix and analyte ionization. J. Mass Spectrom 45, 333–346 (2010)
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