Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL

Author:

Jancekova Blanka,Ondrouskova Eva,Knopfova Lucia,Smarda Jan,Benes Petr

Funder

European Regional Development Fund

IGA, Ministry of Health of the Czech Republic

MEYS of the Czech Republic

MMCI

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Reference56 articles.

1. Benes P, Vetvicka V, Fusek M. Cathepsin D—many functions of one aspartic protease. Crit Rev Oncol Hematol. 2008;68:12–28.

2. Margaryan NV, Kirschmann DA, Lipavsky A, Bailey CM, Hendrix MJC, Khalkhali-Ellis Z. New insights into cathepsin D in mammary tissue development and remodeling. Cancer Biol Ther. 2010;10:457–66.

3. Têtu B, Brisson J, Lapointe H, Wang CS, Bernard P, Blanchette C. Cathepsin D expression by cancer and stromal cells in breast cancer: an immunohistochemical study of 1348 cases. Breast Cancer Res Treat. 1999;55:137–47.

4. Fitzgibbons PL, Page DL, Weaver D, Thor AD, Allred DC, Clark GM, et al. Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000;124:966–78.

5. Garcia M, Derocq D, Pujol P, Rochefort H. Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency. Oncogene. 1990;5:1809–14.

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