Recombinant Factor VII Activated and Prothrombin Complex Concentrate Use at a Tertiary Academic Medical Center
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s40138-014-0046-6.pdf
Reference22 articles.
1. Bruce D, Nokes TJC. Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital. Crit Care. 2008;12:R105.
2. Lynn M, Jeroukhimov I, Klein Y, et al. Updates in the management of severe coagulopathy in trauma patients. Int Care Med. 2002;28:S241–7.
3. •• Vang ML, Hvas AM, Ravn HB. Urgent reversal of vitamin K antagonist therapy. Acta Anaesthesiol Scand. 2011;55:507–16. This article provides the rationale and evidence supporting the use of prothrombin complex concentrates, fresh frozen plasma, and recombinant Factor VII activated in the reversal of vitamin K antagonists. Reversal of vitamin K antagonists was the most common reason for factor administration at our institution.
4. Ho AMH, Dion PW, Cheng CAY, et al. A mathematical model for fresh frozen plasma transfusion strategies during major trauma resuscitation with ongoing hemorrhage. Can J Surg. 2005;48(6):470–8.
5. • Voils S. Pharmacologic interventions for the management of critical bleeding. Pharmacotherapy. 2007;27(9:2):69S–84S. This article summarizes pharmacological interventions for the management of acute bleeding due to many different coagulopathies. It provides evidence and dosing strategies for available agents.
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