Abstract
AbstractThis study analyzed hospital admissions for invasive meningococcal disease (IMD) in epidemiological and economic terms in Italy from 2015 to 2019. The volume of acute admissions for meningococcal diagnosis was analyzed in the period from 2015 to 2019. IMD admissions were identified by ICD-9-CM diagnoses. Costs were assessed using current DRG tariffs. In 2019, a total of 237 admissions for meningococcal disease were recorded in Italy. The mean age of patients was 36.1 years. Lumbar puncture was reported in only 14% of hospital discharge forms. From 2015 to 2019, there was a mean annual reduction of − 1.2% nationally for IMD hospitalizations. For 2019, the total costs for acute inpatient admissions were €2,001,093. Considering annual incidence due to IMD, a significant decrease was noted in the age group from 0 to 1 year (p = 0.010) during 2015–2019. For all years, mortality associated with meningeal syndrome was lower compared to septic shock with or without meningitis. From 2015 to 2019, hospitalizations for IMD appear to be decreasing slightly in Italy, even if mortality remains high. Favorable trends in hospitalizations for IMD were seen in the 0–1-year age group, which may be attributable to increased vaccination. Costs of hospitalizations for IMD remain high.
Funder
Università degli Studi di Udine
Publisher
Springer Science and Business Media LLC
Subject
Emergency Medicine,Internal Medicine
Reference44 articles.
1. Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes JM (2001) Meningococcal disease. N Engl J Med 344(18):1378–1388. https://doi.org/10.1056/NEJM200105033441807
2. Thompson MJ, Ninis N, Perera R, Mayon-White R, Phillips C, Bailey L et al (2006) Clinical recognition of meningococcal disease in children and adolescents. Lancet 367(9508):397–403. https://doi.org/10.1016/S0140-6736(06)67932-4
3. Purmohamad A, Abasi E, Azimi T, Hosseini S, Safari H, Nasiri MJ et al (2019) Global estimate of Neisseria meningitidis serogroups proportion in invasive meningococcal disease: a systematic review and meta-analysis. Microb Pathog. https://doi.org/10.1016/j.micpath.2019.103571
4. European Centre for Disease Prevention and Control (2018) Annual epidemiological report for Invasive meningococcal disease. https://www.ecdc.europa.eu/sites/default/files/documents/AER-Invasive-meningococcal-disease-2018.pdf. Accessed 25 May 2023
5. Trotter CL, Ramsay ME (2007) Vaccination against meningococcal disease in Europe: review and recommendations for the use of conjugate vaccines. FEMS Microbiol Rev 31(1):101–107. https://doi.org/10.1111/j.1574-6976.2006.00053.x
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献