How histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate
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Published:2024-09-13
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ISSN:1828-0447
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Container-title:Internal and Emergency Medicine
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language:en
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Short-container-title:Intern Emerg Med
Author:
Andrulli SimeoneORCID, Gigante Antonietta, Rossini Michele, D’Angio’ Pierluigi, Vischini Gisella, Luchetta Franca, Aucella Filippo, Valsecchi Giovanni, Infante Barbara, Vario Maria Giovanna, Giannese Domenico, Granata Antonio, Moggia Elisabetta, Gembillo Guido, Cianci Rosario, Bonomini Mario, Manenti Flavia, Lazzarin Roberta, Renzo Brigida Di, Zanchelli Fulvia, Garozzo Maurizio, Manes Massimo, Battaglia Yuri, Sciri Raffaela, Fabritiis Marco De, Quaglia Marco, Cavoli Gioacchino Li, Gintoli Enrica, Conte Maria Maddalena, Borzumati Maurizio, Benozzi Luisa, Pasquariello Giovanna, Andrulli Giovanni, Leoni Marco, Seminara Giuseppe, Corbani Valentina, Sabiu Gianmarco, Maggio Arcangelo Di, Pollastro Rosa Maria, Gesualdo Loreto,
Abstract
AbstractThe evaluation of estimated GFR (eGFR) is a pivotal staging step in patients with chronic kidney disease (CKD), and renal ultrasound plays an important role in diagnosis, prognosis and progression of CKD. The interaction between histopathological diagnosis and ultrasound parameters in eGFR determination has not been fully investigated yet. The study examined the results of native kidney biopsies performed in 48 Italian centers between 2012 and 2020. The primary goal was if and how the histopathological diagnosis influences the relationship between ultrasound parameters and eGFR. After exclusion of children, patients with acute kidney injury and patients without measure of kidney length or parenchymal thickness, 2795 patients have been selected for analysis. The median values were 52 years for patient age, 11 cm for bipolar kidney diameter, 16 mm for parenchymal thickness, 2.5 g/day for proteinuria and 70 ml/min/1.73 m2 for eGFR. The bipolar kidney diameter and the parenchymal thickness were directly related with eGFR values (R square 0.064). Diabetes and proteinuria were associated with a consistent reduction of eGFR, improving the adjusted R square up to 0.100. Addition of histopathological diagnosis in the model increased the adjusted R square to 0.216. There is a significant interaction between histopathological diagnosis and longitudinal kidney diameter (P 0.006). Renal bipolar length and parenchymal thickness are directly related with eGFR. The magnitude of proteinuria and histopathological kidney diagnosis are associated with eGFR. The relationship between kidney length and the level of eGFR depends on the nature of the kidney disease.
Funder
Università degli Studi di Bari Aldo Moro
Publisher
Springer Science and Business Media LLC
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