Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry
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Published:2022-04-21
Issue:6
Volume:17
Page:1651-1660
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ISSN:1828-0447
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Container-title:Internal and Emergency Medicine
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language:en
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Short-container-title:Intern Emerg Med
Author:
De Giorgi AlfredoORCID, Marra Alberto Maria, Iacoviello Massimo, Triggiani Vincenzo, Rengo Giuseppe, Cacciatore Francesco, Maiello Ciro, Limongelli Giuseppe, Masarone Daniele, Perticone Francesco, Filardi Pasquale Perrone, Paolillo Stefania, Mancini Antonio, Volterrani Maurizio, Vriz Olga, Castello Roberto, Passantino Andrea, Campo Michela, Modesti Pietro Amedeo, Salzano Andrea, D’Assante Roberta, Arcopinto Michele, Raparelli Valeria, Fabbian Fabio, Sciacqua Angela, Colao Annamaria, Suzuki Toru, Bossone Eduardo, Cittadini Antonio, Cittadini A., ArcopintoSalzano M. A., Saccà L., Monti M. G., Napoli R., Matarazzo M., Stagnaro F. M., Schiavo A., Valente P., Bossone E., Ferrara F., Russo V., Malinconico M., Citro R., Guastalamacchia E., Iacoviello M., Leone M., Triggiani V., Cacciatore F., Maiello C., Amarelli C., Mattucci I., Limongelli G., Masarone D., Calabrò P., Calabrò R., D’Andrea A., Maddaloni V., Pacileo G., Scarafile R., Perticone F., Belfiore A., Sci-acqua A., Cimellaro A., Filardi P. Perrone, Casaretti L., Paolillo S., Gargiulo P., Mancini A., Favuzzi A. M. R., Di Segni C., Bruno C., Vergani E., Vriz O., Castello R., Frigo A., Campo M., Sorrentino M. R., Modesti P. A., Malandrino D., Manfredini R., De Giorgi A., Fabbian F., Puzzo A., Ragusa L., Caliendo L., Carbone L., Frigiola A., Generali T., Giacomazzi F., De Vincentiis C., Ballotta A., Garofalo P., Malizia G., Suzuki T., Heaney L. M., Bruzzese D.,
Abstract
Abstract
Introduction
Data from the “Trattamento Ormonale nello Scompenso CArdiaco” (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry.
Methods
At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM.
Results
337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV–V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels.
Conclusions
Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF.
Publisher
Springer Science and Business Media LLC
Subject
Emergency Medicine,Internal Medicine
Cited by
3 articles.
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