Identification and quantitation of mifepristone and its N-demethyl metabolite in the plasma of an aborted fetus by liquid chromatography–quadrupole–time-of-flight–mass spectrometry (LC–Q–TOFMS) and ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS

Identification and quantitation of mifepristone and its N-demethyl metabolite in the plasma of an aborted fetus by liquid chromatography–quadrupole–time-of-flight–mass spectrometry (LC–Q–TOFMS) and ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS–MS)

Published:2015-06-12 Issue:2 Volume:33 Page:409-412
ISSN:1860-8965
Container-title:Forensic Toxicology
language:en
Short-container-title:Forensic Toxicol

Author:

Ishii Akira,Zaitsu Kei,Kusano Maiko,Asano Tomomi,Ogawa Tadashi,Hattori Hideki,Seno Hiroshi

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry (medical),Toxicology,Pathology and Forensic Medicine

Link

http://link.springer.com/content/pdf/10.1007/s11419-015-0284-7.pdf

Reference25 articles.

1. Sarkar NN (2002) Mifepristone: bioavailability, pharmacokinetics and use-effectiveness. Eur J Obsterics Gynecol 101:113–120

2. Kekkonen R, Heikinheimo O, Mandelin E, Lähteenmäki P (1996) Pharmacokinetics of mifepristone after low oral doses. Contraception 54:229–234

3. Heikinheimo O (1997) Clinical pharmacokinetics of mifepristone. Drug Disposition 33:7–17

4. Heikinheimo O, Kekkonen R, Lähteenmäki P (2003) The pharmacokinetics of mifepristone in humans reveal insights into differential mechanisms of antiprogestin action. Contraception 68:421–426

5. Ministry of Health, Labour and Welfare (2004) Warning to the public on Mifeprex (an oral abortifacient which is not approved in Japan). (In Japanese) http://www.mhlw.go.jp/houdou/2004/10/h1025-5.html (accessed 7 May 2015)

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