Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers

Author:

Wu Xi-Xi,Huang Xie-Lin,Chen Ru-Ru,Li Tang,Ye Hua-Jun,Xie Wei,Huang Zhi-Ming,Cao Gao-ZhongORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Reference34 articles.

1. Bazzoni, Gianfranco, and Elisabetta Dejana. 2004. Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis. Physiological Reviews 84 (3): 869–901.

2. Chang, K.W., and C.Y. Kuo. 2015. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food & Function 6 (10): 3334–3341. https://doi.org/10.1039/c5fo00513b .

3. Chen, Qianru, Oliver Chen, Isabela M. Martins, Hou Hu, Zhao Xue, Jeffrey B. Blumberg, and Bafang Li. 2017. Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions. Food & Function 8 (3): 1144–1151. https://doi.org/10.1039/c6fo01347c .

4. Chen, J., M. Zhang, M. Zhu, J. Gu, J. Song, L. Cui, D. Liu, Q. Ning, X. Jia, and L. Feng. 2018. Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1alpha/NF-kappaB signaling pathway. Food & Function 9 (4): 2386–2397. https://doi.org/10.1039/c7fo01406f .

5. Cocetta, V., D. Catanzaro, V. Borgonetti, E. Ragazzi, M.C. Giron, P. Governa, I. Carnevali, M. Biagi, and M. Montopoli. 2019. A fixed combination of probiotics and herbal extracts attenuates intestinal barrier dysfunction from inflammatory stress in an in vitro model using Caco-2 cells. Recent Patents on Food, Nutrition & Agriculture 10 (1): 62–69. https://doi.org/10.2174/2212798410666180808121328 .

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