Inhibition of epidermal growth factor binding to Swiss 3T3 cells by human platelet release-products-Reference-Cited by-同舟云学术

Inhibition of epidermal growth factor binding to Swiss 3T3 cells by human platelet release-products

Published:1983-07-01 Issue:7 Volume:3 Page:659-666
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Brown Kenneth D.¹,Blakeley Diane M.¹,MacDonald Moira²

Affiliation:

1. ARC Institute of Animal Physiology, Babraham, Cambridge CB2 4AT, UK

2. Headquarters Laboratory, Scottish National Blood Transfusion Service, 2 Forrest Road, Edinburgh EH1 2QN, UK

Abstract

Human platelet ionophore release-products (IRP) inhibit the binding of 125I-labelled epidermal growth factor (125I-EGF) to its receptors on Swiss 3T3 cells. The inhibition appears to be caused by platelet-derived growth factor (PDGF) in the IRP and results from a decrease in the apparent affinity of cellular receptors for 125I-EGF. However, our results indicate that PDGF does not bind directly to EGF receptors, since (1) PDGF does not down-regulate EGF receptors; (2) the PDGF-mediated inhibition of 125I-EGF binding is temperature-dependent; (3) cells which possess EGF receptors but lack PDGF receptors do not exhibit a PDGF-mediated inhibition of 125I-EGF binding.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/3/7/659/470883/bsr0030659.pdf

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