Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for ?1-adrenoceptor binding sites

Author:

Gro� Gerhard,Hanft Gertraud,Kolassa Norbert

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference27 articles.

1. Bevan P, Tulp MThM, Wouters W (1986a) Are 5-HT1A binding sites relevant for the antihypertensive effects of DU 29373? Br J Pharmacol 89:637P

2. Bevan P, Ramage AG, Wouters W (1986b) Investigation of the effects of DU 29373 on the cardiovascular system of the anaesthetised cat. Br J Pharmacol 89:506P

3. Bockaert J, Dumuis A, Bouhelal R, Sebben M, Cory RN (1987) Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons. Naunyn-Schmiedeberg's Arch Pharmacol 335:588?592

4. Coote JH, Dalton DW, Feniuk W, Humphrey PPA (1987) The central site of the sympatho-inhibitory action of 5-hydroxytryptamine in the cat. Neuropharmacology 26:147?154

5. De Vivo M, Maayani S (1986) Characterization of the 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes. Naunyn-Schmiedeberg's Arch Pharmacol 335:588?592

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