Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes

Author:

Zamboni William C.,Ramanathan Ramesh K.,McLeod Howard L.,Mani Sridhar,Potter Douglas M.,Strychor Sandra,Maruca Lauren J.,King Cristi R.,Jung Laura L.,Parise Robert A.,Egorin Merrill J.,Davis Todd A.,Marsh Sharon

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference45 articles.

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3. Drengler RL, Kuhn JG, Schaaf LJ, et al (1999) Phase I and pharmacokinetic trial of oral irinotecan administered daily for 5 days every 3 weeks in patients with solid tumors. J Clin Oncol 17:685–696

4. Loos WJ, Gelderblom H, Sparreboom A, Verweij J, de Jonge MJ (2000) Inter- and intrapatient variability in oral topotecan pharmacokinetics: implications for body-surface area dosage regimens. Clin Cancer Res 6:2685–2689

5. Kruijtzer CM, Beijnen JH, Rosing H, et al (2002) Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918. J Clin Oncol 20:2943–2950

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