Phase II clinical trial of pazopanib in patients with acute myeloid leukemia (AML), relapsed or refractory or at initial diagnosis without an intensive treatment option (PazoAML)

Author:

Kessler Torsten,Koschmieder Steffen,Schliemann Christoph,Crysandt Martina,Mikesch Jan-Henrik,von Stillfried Saskia,Stelljes Matthias,Pohlen Michele,Lenz Georg,Kirsch Anna,Vehring Kerstin,Wardelmann Eva,Hartmann Wolfgang,Bormann Eike,Gerss Joachim,Brümmendorf Tim H.,Müller-Tidow Carsten,Berdel Wolfgang E.ORCID

Funder

Deutsche Forschungsgemeinschaft

GlaxoSmithKline

Novartis Pharma

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference25 articles.

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3. Metzelder S, Wang Y, Wollmer E, Wanzel M, Teichler S, Chaturvedi A, Eilers M, Enghofer E, Neubauer A, Burchert A (2009) Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation. Blood 113(26):6567–6571. https://doi.org/10.1182/blood-2009-03-208298

4. Stone RM, Mandrekar SJ, Sanford BL, Laumann K, Geyer S, Bloomfield CD, Thiede C, Prior TW, Dohner K, Marcucci G, Lo-Coco F, Klisovic RB, Wei A, Sierra J, Sanz MA, Brandwein JM, de Witte T, Niederwieser D, Appelbaum FR, Medeiros BC, Tallman MS, Krauter J, Schlenk RF, Ganser A, Serve H, Ehninger G, Amadori S, Larson RA, Dohner H (2017) Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation. N Engl J Med 377(5):454–464. https://doi.org/10.1056/NEJMoa1614359

5. Ikeda H, Kanakura Y, Tamaki T, Kuriu A, Kitayama H, Ishikawa J, Kanayama Y, Yonezawa T, Tarui S, Griffin JD (1991) Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells. Blood 78(11):2962–2968

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