Daratumumab, bortezomib, melphalan, and prednisone versus bortezomib, melphalan, and prednisone alone in transplant-ineligible Asian patients with newly diagnosed multiple myeloma: final analysis of the phase 3 OCTANS Study

Author:

Fu Weijun,Bang Soo-Mee,Huang Honghui,Kim Kihyun,Li Wei,An Gang,Lee Je-Jung,Cai Zhen,Jin Jie,Wang Yafei,Chim Chor Sang,Carson Robin,Liu Rui,Zhao Man,Chen Xi,Cui Canchan,Hou Jian,Wang Jianxiang

Funder

Janssen Research & Development, LLC

Publisher

Springer Science and Business Media LLC

Reference23 articles.

1. de Weers M, Tai YT, van der Veer MS, Bakker JM, Vink T, Jacobs DC, Oomen LA, Peipp M, Valerius T, Slootstra JW, Mutis T, Bleeker WK, Anderson KC, Lokhorst HM, van de Winkel JG, Parren PW (2011) Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors. J Immunol 186:1840–1848. https://doi.org/10.4049/jimmunol.1003032

2. Lammerts van Bueren J, Jakobs D, Kaldenhoven N, Roza M, Hiddingh S, Meesters J, Voorhorst M, Gresnigt E, Wiegman L, Buijsse O, Andringa G, Overdijk MB, Doshi P, Sasser K, de Weers M, Parren PW (2014) Direct in vitro comparison of daratumumab with surrogate analogs of CD38 antibodies MOR03087, SAR650984 and Ab79. Blood 124:3474. https://doi.org/10.1182/blood.V124.21.3474.3474

3. Overdijk MB, Verploegen S, Bogels M, van Egmond M, Lammerts van Bueren J, Mutis T, Groen RW, Breij E, Martens AC, Bleeker WK, Parren PW (2015) Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma. MAbs 7:311–321. https://doi.org/10.1080/19420862.2015.1007813

4. Overdijk MB, Jansen JH, Nederend M, Lammerts van Bueren J, Groen RW, Parren PW, Leusen JH, Boross P (2016) The therapeutic CD38 monoclonal antibody daratumumab induces programmed cell death via fcgamma receptor-mediated cross-linking. J Immunol 197:807–813. https://doi.org/10.4049/jimmunol.1501351

5. Krejcik J, Casneuf T, Nijhof IS, Verbist B, Bald J, Plesner T, Syed K, Liu K, van de Donk NWCJ, Weiss BM, Ahmadi T, Lokhorst HM, Mutis T, Sasser AK (2016) Daratumumab depletes CD38+ immune-regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma. Blood 128:384–394. https://doi.org/10.1182/blood-2015-12-687749

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