What Is the Place of PARP Inhibitors in Ovarian Cancer Treatment?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
http://link.springer.com/content/pdf/10.1007/s11912-016-0515-z.pdf
Reference47 articles.
1. Ame JC, Spenlehauer C, de Murcia G. The PARP superfamily. Bioessays. 2004;26(8):882–93. eng.
2. Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005;434(7035):913–7. eng.
3. Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434(7035):917–21. eng.
4. Cancer Genome Atlas Research N. Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474(7353):609–15. Pubmed Central PMCID: 3163504. This publication describes findings from analyzing messenger RNA expression, microRNA expression, promoter methylation, and DNA copy number in 489 HGSOCs and exon sequencing in 316 of these samples. Importantly, it describes that ∼50% of HGSOC have a molecular alteration in genes involved in HR and may therefore have increased susceptibility to PARP inhibition.
5. Konstantinopoulos PA, Ceccaldi R, Shapiro GI, D’Andrea AD. Homologous recombination deficiency: exploiting the fundamental vulnerability of ovarian cancer. Cancer Discov. 2015;5(11):1137–54. Pubmed Central PMCID: 4631624.
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