Can Anthracycline Therapy for Pediatric Malignancies Be Less Cardiotoxic?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
http://link.springer.com/content/pdf/10.1007/s11912-010-0129-9.pdf
Reference49 articles.
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3. Von Hoff DD, Rozencweig M, Layard M, et al.: Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases. Am J Med 1977, 62:200–208.
4. Anderson B: Dexrazoxane for the prevention of cardiomyopathy in anthracycline treated pediatric cancer patients. Pediatr Blood Cancer 2005, 44:584–588.
5. • Barry EV, Vrooman LM, Dahlberg SE, et al.: Absence of secondary malignant neoplasms in children with high-risk acute lymphoblastic leukemia treated with dexrazoxane. J Clin Oncol 2008, 26:1106–1111. The concern over the increased risk of secondary malignancies is a reason some clinicians are reluctant to use dexrazoxane. The authors dispute this concern by demonstrating in a study of 205 children dexrazoxane does not increase the risk of secondary malignancies (P = 0.66).
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