Investigation of [3H]diazepam derivatives as allosteric modulators of GABAA receptor α1β2γ2 subtypes: combination of molecular docking/dynamic simulations, pharmacokinetics/drug-likeness prediction, and QSAR analysis-Reference-Cited by-同舟云学术

Investigation of [3H]diazepam derivatives as allosteric modulators of GABAA receptor α1β2γ2 subtypes: combination of molecular docking/dynamic simulations, pharmacokinetics/drug-likeness prediction, and QSAR analysis

Published:2022-08-11 Issue: Volume: Page:
ISSN:1040-0400
Container-title:Structural Chemistry
language:en
Short-container-title:Struct Chem

Author:

Djebaili Rachida,Kenouche Samir,Daoud Ismail^ORCID,Melkemi Nadjib,Belkadi Ahlem,Mesli Fouzia

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry,Condensed Matter Physics

Link

https://link.springer.com/content/pdf/10.1007/s11224-022-02029-4.pdf

Reference66 articles.

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2. Zhu S, Noviello CM, Teng J, Walsh RM, Kim JJ, Hibbs RE (2018) Structure of a human synaptic GABAA receptor. Nature 559:67–88. https://doi.org/10.1038/s41586-018-0255-3

3. Sigel E, Steinmann ME (2012) Structure, function, and modulation of GABAA receptors. J Biol Chem 287:40224–40231. https://doi.org/10.1074/jbc.R112.386664

4. Miller PS, Aricescu AR (2014) Crystal structure of a human GABAA receptor. Nature 512:270–275. https://doi.org/10.1038/nature13293

5. Olsen RW, Sieghart W (2008) International Union of Pharmacology. LXX. Subtypes of γ-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology, and function. Update Pharmacol Rev 60:243–260. https://doi.org/10.1124/pr.108.00505

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