Precipitation of complex antibody solutions: influence of contaminant composition and cell culture medium on the precipitation behavior

Author:

Großhans SteffenORCID,Suhm Susanna,Hubbuch Jürgen

Funder

European Union: Horizon 2020 Research and Innovation Programme

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Bioengineering,Biotechnology

Reference42 articles.

1. Walther J, Godawat R, Hwang C, Abe Y, Sinclair A, Konstantinov K (2015) The business impact of an integrated continuous biomanufacturing platform for recombinant protein production. J Biotechnol 213:3–12

2. Farid SS (2007) Process economics of industrial monoclonal antibody manufacture. J Chromatogr B 848(1):8–18

3. Kelley B (2009) Industrialization of mAb production technology: the bioprocessing industry at a crossroads. mAbs, vol 1. Taylor & Francis, Abingdon, pp 443–452

4. Beck A, Reichert JM (2013) Approval of the first biosimilar antibodies in Europe: a major landmark for the biopharmaceutical industry. mAbs, vol 5. Taylor & Francis, Abingdon, pp 621–623

5. Yoo DH (2014) The rise of biosimilars: potential benefits and drawbacks in rheumatoid arthritis. Expert Revi Clin Immunol 10(8):981–983. https://doi.org/10.1586/1744666X.2014.932690

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