A novel monospecific tetravalent IgG1-(scFv)2 version shown enhanced neutralizing and Fc-mediated effector functions against SARS-CoV-2
Author:
Funder
National Key R&D Program of China
Publisher
Springer Science and Business Media LLC
Subject
Agricultural and Biological Sciences (miscellaneous),Environmental Science (miscellaneous),Biotechnology
Link
https://link.springer.com/content/pdf/10.1007/s13205-023-03702-z.pdf
Reference32 articles.
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2. Atal S, Fatima Z (2020) IL-6 inhibitors in the treatment of serious covid-19: a promising therapy? Pharmaceut Med 34(4):223–231. https://doi.org/10.1007/s40290-020-00342-z
3. Banu N, Panikar SS, Leal LR et al (2020) Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications. Life Sci 256:117905. https://doi.org/10.1016/j.lfs.2020.117905
4. Beaudoin-Bussières G, Chen Y, Ullah I et al (2022) A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection. Cell Rep 38 (7), 110368, doi:https://doi.org/10.1016/j.celrep.2022.110368.
5. Bhattacharya M, Chatterjee S, Mallik B et al (2022) Therapeutic role of neutralizing antibody for the treatment against SARS-CoV-2 and its emerging variants: a clinical and pre-clinical perspective. Vaccines 10(10):1612. https://doi.org/10.3390/vaccines10101612
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