Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures
Author:
Funder
AstraZeneca Schweiz
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology
Link
http://link.springer.com/content/pdf/10.1007/s11095-021-02987-0.pdf
Reference43 articles.
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3. Razinkov VI, Treuheit MJ, Becker GW. Accelerated formulation development of monoclonal antibodies (mAbs) and mAb-based modalities: review of methods and tools. J Biomol Screen. 2015;20(4):468–83. https://doi.org/10.1177/1087057114565593.
4. Jiskoot W, Randolph TW, Volkin DB, Russell Middaugh C, Schöneich C, Winter G, et al. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. J Pharm Sci. 2012;101(3):946–54. https://doi.org/10.1002/jps.23018.
5. Shire SJ, Shahrokh Z, Liu J. Challenges in the development of high protein concentration formulations. J Pharm Sci. 2004;93(6):1390–402. https://doi.org/10.1002/jps.20079.
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