N-Nitrosodialkylamine dealkylation in reconstituted systems containing cytochrome P-450 purified from phenobarbitaland β-naphthoflavone-treated rats

Author:

Kawanishi T.,Ohno Y.,Takanaka A.,Kawano S.,Yamazoe Y.,Kato R.,Omori Y.

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference33 articles.

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3. Druckrey H, Preussmann R, Ivankovic S, Schmähl D (1967) Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitrosoverbindungen an BD-Ratten. Z Krebsforsch 69: 103–201

4. Guengerich FP, Dannan GA, Wright ST, Martin MV, Kaminsky LS (1982) Purification and characterization of liver microsomal cytochrome P-450: electrophoretic, spectral, catalytic, and immunological properties and inducibility of eight isozymes isolated from rat treated with phenobarbital or β-naphthoflavone. Biochemistry 21: 6019–6030

5. Ji C, Mirvish SS, Nickols J, Ishizaki H, Lee MJ, Yang CS (1989) Formation of hydroxy derivatives, aldehydes and nitrite from N-nitrosomethyl-n-amylamine by rat liver microsomes and by cytochrome P-450IIB1. Cancer Res 49: 5299–5304

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