Design, synthesis and biological evaluation of novel thiophene and theinopyrimidine derivatives as anticancer agents

Author:

Labib Madlen B.,Lamie Phoebe F.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference28 articles.

1. Abu-Hashem AA, El-Shehry MF, Badria FA (2010) Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents. Acta Pharm 60:311–323

2. Aliabadia A, Foroumadib A, Safavic M, Ardestani SK (2012) Synthesis, molecular docking and cytotoxicity evaluation of 2-(4-substituted-benzyl)isoindoline-1,3-dione derivatives as anticancer agents. J Rep Pharm Sci 1(1):23–26

3. Al-Soud YA (2007) Synthesis and anti-HIV activity of substituted 1,2,4-triazolothiophene derivatives. Heteroatom Chem 18(4):443–448

4. Amr AE, Sherif MH, Assy MG, Al-Omara MA, Ragab I (2010) Antiarrhythmic, serotonin antagonist and antianxiety activities of novel substituted thiophene derivatives synthesized from 2-amino-4,5,6,7-tetrahydro-N-phenylbenzo[b]thiophene-3-carboxamide. Eur J Med Chem 45(12):5935–4592

5. Babatin MM, Khezami L, Barakat A, El-Gazzar A (2011) Simple and efficient synthesis of novel glycosyl thiourea derivatives derived from thiophene as potential antitumor agents. J Chem Chem Eng 5:73–81

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