Synthesis and evaluation of κ-opioid receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α,14α-endo-etheno-tetrahydrothebaine with substituted o-, m- and p-amino group-Reference-Cited by-同舟云学术

Synthesis and evaluation of κ-opioid receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α,14α-endo-etheno-tetrahydrothebaine with substituted o-, m- and p-amino group

Published:2010-11-17 Issue:8 Volume:20 Page:1364-1370
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Qi Hong,Li Wei,Qiu Yu,Cui Yong-yao,Ma Jian,Gao Xiao-ling,Zeng Yi-bin,Yang Jie,Tang Yun,Wang Xing-hai,Sheng Wei,Xie Qiong,Liu Jing-geng,Qiu Zhui-bai,Chen Hong-zhuan

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/s00044-010-9471-6.pdf

Reference19 articles.

1. Aldrich JV, McLaughlin JP (2009) Peptide kappa opioid receptor ligands: potential for drug development. AAPS J 11:312–322

2. Bentley KW, Hardy DG (1967) Novel analgesics and molecular rearrangements in the morphine-thebaine group. I. Ketones derived from derived from 6,14-endo-ethenotetrahydrothebaine. J Am Chem Soc 89:3267–3273

3. Bentley KW, Hardy DG, Meek B (1967) Novel analgesics and molecular rearrangements in the morphine-thebaine group. II. Alcohols derived from 6,14-endo-etheno- and 6,14-endo-ethanotetrahydrothebaine. J Am Chem Soc 89:3273–3280

4. Casy AF, Parfitt RT (1986) Opioid analgesics: chemistry and receptors. Plenum, New York, p 518

5. Christo PJ, Mazloomdoost D (2008) Cancer pain and analgesia. Ann N Y Acad Sci 1138:278–298

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology;The Journal of Biochemistry;2024-02-21

2. Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone;European Journal of Medicinal Chemistry;2023-10

3. SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity;Journal of Medicinal Chemistry;2022-07-28

4. Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion;Acta Pharmacologica Sinica;2021-09-07

5. Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile;Journal of Medicinal Chemistry;2021-08-13