Comprehensive structure–activity relationship analysis of substituted 5-(biphenyl-4-ylmethyl) pyrazoles derivatives as AT1 selective angiotensin II receptor antagonists: 2D and kNNMFA QSAR approach-Reference-Cited by-同舟云学术

Comprehensive structure–activity relationship analysis of substituted 5-(biphenyl-4-ylmethyl) pyrazoles derivatives as AT1 selective angiotensin II receptor antagonists: 2D and kNNMFA QSAR approach

Published:2012-09-23 Issue:5 Volume:22 Page:2124-2138
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Sharma Mukesh C.,Kohli D. V.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/s00044-012-0206-8.pdf

Reference67 articles.

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3. Carmen A, Luis AG, Fernando LC, de Alberto A F, Julian GR, Javier F (1997) Synthesis and structure-activity relationship of a new series of potent AT1 selective angiotensin ii receptor antagonists: 5-(Biphenyl-4-ylmethyl)pyrazoles. J Med Chem 40:547–558

4. Catt KJ,Sandberg K, Balla T(1993) Angiotensin II receptors and signal transduction mechanisms. In: Raizada MK, Philips MI, Sumners C (eds) Cellular and molecular biology of the renin angiotensin system. CRC Press Inc., Boca Raton

5. Cramer RD, Patterson DE, Bunce JD (1988) Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins. J Am Chem Soc 110:5959–5967

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