Update on the Pathophysiology of Interstitial Cystitis /Bladder Pain Syndrome

Author:

Akiyama Yoshiyuki

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Biochemistry

Reference84 articles.

1. Hanno PM, Erickson D, Moldwin R, Faraday MM, American Urological A. Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment. J Urol. 2015;193(5):1545–53. https://doi.org/10.1016/j.juro.2015.01.086.

2. Akiyama Y, Homma Y, Maeda D. Pathology and terminology of interstitial cystitis/bladder pain syndrome: a review. Histol Histopathol. 2019;34:25–32. https://doi.org/10.14670/HH-18-028.

3. •• Akiyama Y, Maeda D, Katoh H, Morikawa T, Niimi A, Nomiya A, et al. Molecular taxonomy of interstitial cystitis/bladder pain syndrome based on whole transcriptome profiling by next-generation RNA sequencing of bladder mucosal biopsies. J Urol. 2019;202:290–300. https://doi.org/10.1097/JU.0000000000000234Whole transcriptome and quantitative microvascularity analyses revealed distinct gene expression and microvascularity in IC/BPS with Hunner lesions.

4. Chennamsetty A, Khourdaji I, Goike J, Killinger KA, Girdler B, Peters KM. Electrosurgical management of Hunner ulcers in a referral center's interstitial cystitis population. Urology. 2015;85(1):74–8. https://doi.org/10.1016/j.urology.2014.09.012.

5. •• Maeda D, Akiyama Y, Morikawa T, Kunita A, Ota Y, Katoh H, et al. Hunner-type (classic) interstitial cystitis: a distinct inflammatory disorder characterized by pancystitis, with frequent expansion of clonal B-cells and epithelial denudation. PLoS One. 2015;10(11):e0143316. https://doi.org/10.1371/journal.pone.0143316Quantitative histological analysis revealed epithelial denudation and B cell clonal expansion as distinct and crucial histological features of IC/BPS with Hunner lesions.

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