Author:
Juste-Dolz Augusto,Teixeira William,Pallás-Tamarit Yeray,Carballido-Fernández Mario,Carrascosa Javier,Morán-Porcar Ángela,Redón-Badenas María Ángeles,Pla-Roses María Gracia,Tirado-Balaguer María Dolores,Remolar-Quintana María José,Ortiz-Carrera Jon,Ibañez-Echevarría Ethel,Maquieira Angel,Giménez-Romero David
Abstract
AbstractThe biosensor, named “virusmeter” in this study, integrates quartz crystal microbalance technology with an immune-functionalized chip to distinguish between symptomatic patients with respiratory diseases and healthy individuals by analyzing exhaled air samples. Renowned for its compact design, rapidity, and noninvasive nature, this device yields results within a 5-min timeframe. Evaluated under controlled conditions with 54 hospitalized symptomatic COVID-19 patients and 128 control subjects, the biosensor demonstrated good overall sensitivity (98.15%, 95% CI 90.1–100.0) and specificity (96.87%, 95% CI 92.2–99.1). This proof-of-concept presents an innovative approach with significant potential for leveraging piezoelectric sensors to diagnose respiratory diseases.
Graphical abstract
Funder
Generalitat Valenciana
University of Valencia and INCLIVA|VLC Biomedical Research Institute
Universitat de Valencia
Publisher
Springer Science and Business Media LLC
Reference53 articles.
1. World Health Organization. World Health Assembly to focus on ending COVID-19 pandemic and preparing for next one. 2021. https://www.who.int/news/item/19-05-2021-world-health-assembly-to-focus-on-ending-covid-19-pandemic-and-preparing-for-next-one. Accessed 1 Feb 2024
2. Tang JW, Tellier R, Li Y. Hypothesis: all respiratory viruses (including SARS-CoV-2) are aerosol-transmitted. Indoor Air 2022;32:e12937 https://doi.org/10.1111/ina.12937.
3. Roy CJ, Milton DK. Airborne transmission of communicable infection — the elusive pathway. N Engl J Med. 2004;350:1710–2. https://doi.org/10.1056/nejmp048051.
4. Wang CC, Prather KA, Sznitman J, Jimenez JL, Lakdawala SS, Tufekci Z, Marr LC. Airborne transmission of respiratory viruses. Science 2021;373:eabd9149. https://doi.org/10.1126/science.abd9149.
5. Chen R, Yin H, Cole IS, Shen S, Zhou X, Wang Y, Tang S. Exposure, assessment and health hazards of particulate matter in metal additive manufacturing: a review. Chemosphere. 2020;259: 127452. https://doi.org/10.1016/j.chemosphere.2020.127452.