Effects of temperature alteration on viscosity, polymerization, and in-vivo arterial distribution of N-butyl cyanoacrylate-iodized oil mixtures

Author:

Mine TakahikoORCID,Yasui Daisuke,Saito Hidemasa,Ueda Tatsuo,Yokoyama Taro,Ikeda Shinpei,Mizushima Shohei,Happoh Seigoh,Kumita Shin-ichiro

Abstract

Abstract Purpose Temperature alteration can modify the polymerization of n-butyl cyanoacrylate (NBCA)-iodized oil mixtures during vascular embolization; its effects on viscosity, polymerization time, and intra-arterial distribution of the NBCA-iodized oil mixture were investigated. Materials and methods In vitro, the viscosities of NBCA, iodized oil, and NBCA-iodized oil mixtures (ratio, 1:1–8) were measured at 4–60 ºC using a rotational rheometer. The polymerization times (from contact with blood plasma to stasis) were recorded at 0–60 ºC using a high-speed video camera. In vivo, the 1:2 mixture was injected into rabbit renal arteries at 0, 20, and 60 ºC; intra-arterial distribution of the mixture was pathologically evaluated. Results The mixtures’ viscosities decreased as temperature increased; those at 60 ºC were almost four to five times lower than those at 4 ºC. The polymerization time of NBCA and the 1:1–4 mixtures increased as temperature decreased in the 0–30 ºC range; the degree of time prolongation increased as the percentage of iodized oil decreased. The 0 ºC group demonstrated distributions of the mixture within more peripheral arterial branches than the 20 and 60 ºC groups. Conclusion Warming reduces the mixture’s viscosity; cooling prolongs polymerization. Both can be potential factors to improve the handling of NBCA-iodized oil mixtures for lesions requiring peripheral delivery. Secondary abstract Temperature alteration influences the polymerization time, viscosity, and intra-arterial distribution of NBCA-iodized oil mixtures. Warming reduces the viscosity of the mixture, while cooling prolongs polymerization.

Publisher

Springer Science and Business Media LLC

Subject

Radiology Nuclear Medicine and imaging

Reference16 articles.

1. Brothers MF, Kaufmann JC, Fox AJ, Deveikis JP. n-Butyl 2-cyanoacrylate–substitute for IBCA in interventional neuroradiology: histopathologic and polymerization time studies. Am J Neuroradiol. 1989;10:777–86.

2. Gounis MJ, Lieber BB, Wakhloo AK, Siekmann R, Hopkins LN. Effect of glacial acetic acid and ethiodized oil concentration on embolization with N-butyl 2-cyanoacrylate: an in vivo investigation. Am J Neuroradiol. 2002;23:938–44.

3. Mine T, Ueda T, Yasui D, Mizushima S, Kumita SI. Embolization using warmed glue via the triaxial microballoon occlusion system for various vascular disorders. Diagn Interv Radiol. 2020;26:241–4.

4. Mine T, Murata S, Nakazawa K, Onozawa S, Ueda T, Kumita S. Novel endovascular techniques to control in-outflow with dual approach for large pelvic arteriovenous malformation. J Vasc Surg Venous Lymphat Disord. 2013;1:212–5.

5. Mine T, Murata S, Nakazawa K, Onozawa S, Ueda T, Miyauchi, , et al. Glue embolization for gastroduodenal ulcer bleeding: contribution to hemodynamics and healing process. Acta Radiol. 2013;54:934–8.

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