The ethical challenges in rheumatology

Author:

Mckeown Emily J.

Publisher

Springer Science and Business Media LLC

Subject

Orthopedics and Sports Medicine

Reference20 articles.

1. Caplan L, Hoffecker L, Prochazka AV. Ethics in the rheumatology literature: a systematic review. Arthritis Rheum. 2008;59(6):816–21.

2. Mackenzie CR, Meltzer M, Kitsis EA, Mancuso CA. Ethical challenges in rheumatology: a survey of the American college of rheumatology membership. Arthritis Rheum. 2013;65(10):2524–32. This article discusses the important ethical issues identified by American rheumatologists. These include costs related to treatments, profiting from infusions, relationships with industry, and conflict of interest. A commitment to ethics education was suggested.

3. Bonafede M, Joseph GJ, Princic N, Harrison DJ. Annual acquisition and administration cost of biologic response modifiers per patient with rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing spondylitis. J Med Econ. 2013;16(9):1120–8. Using US claims administrative data, actual drug utilization was used to estimate treatment patterns and the annual cost per treated patient with different inflammatory conditions; etanercept was found to be the lowest cost per treated patient.

4. van der Velde G, Pham B, Machado M, Ieraci L, Witteman W, Bombardier C, et al. Cost-effectiveness of biologic response modifiers compared to disease-modifying antirheumatic drugs for rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken). 2011;63(1):65–78. This systematic review looked at different economic evaluations for biologics in patients with rheumatoid arthritis. Biologics were not cost effective in patients with no previous DMARD exposure and patients who failed methotrexate combination therapy or sequential DMARD administration (at a willingness to pay threshold of$ 50,000/Quality of life year). There was evidence of cost-effectiveness in patients who failed methotrexate monotherapy.

5. Hebert PC. Doing right: a practical guide to ethics for medical trainees and physicians. Ontario: Oxford University Press; 1995.

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